Search academic texts

Information × Registration Number 0218U001404, 0116U003568 , R & D reports Title Optimization of methods of treatment of patients with non-alcoholic steatohepatitis in persons exposed to ionizing radiation, on the basis of the correction of metabolic changes and supression persistent infections. popup.stage_title Head Chumak Anatoliy Andreevich, Ovsyannikova Ludmila Mihailovna, Registration Date 08-02-2018 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Report: 103 p., 19 tables, 6 figures, 2 annexes, 159 sources. TREATMENT, METABOLIC CHANGES, NONALCOHOLIC LIVER DISEASES, CONSEQUENCES OF THE ChNPP ACCIDENT, PERSISTENT INFECTION Object of the study: on the basis of selective screening of the hepatobiliary system in 138 victims of the ChNPP accident, the study of the state of anti-infection immunity, indicators of the prooxidant antioxidant system and changes in the indices of these systems based on the results of treatment in 72 patients with non-alcoholic steatohepatitis. The purpose of the work is to determine the effict of treatment of non-alcoholic stecohepatitis using combination therapy (antioxidants and hepatoprotectors) based on the evaluation of metabolic changes and suppression of persistent infections in the victims of the Chernobyl accident. Methods of research general-clinical, immunological, biochemical and instrumental. Equipment: ultrasonic devices Shiwadzu 410 B, Aloka - 2000, Aloka - 650, gastroscope Olympus (all manufactured in Japan), personal computers. Effectiveness of combination therapy with hepatoprotectors and aevit (antioxidant) of non-alcoholic steatohepatitis in the victims of the ChNPP accident with the evaluation of changes in the activity of the herpesvirus infection, the antioxidant system and the functional state of the liver have been studied. After treatment, a decrease in the mean values of the titres of herpes simplex virus (anti-HSV-1/2 IgG) with (4,04 ± 0,88) standart units (3,54 ± 0,76) standart units, cytomegalovirus (anti -CMV IgG) with (4,59 ± 0,63) standart units up to (3,17 ± 0,59) standart units. The titers of the Epstein-Barr virus antibodies both for the cow and for the nuclear did not change and remained elevated after treatment. In the treatment of hepatoprotectors and antioxidants of non-alcoholic steatohepatitis in the victims of the Chernobyl accident, the indexes of lipid peroxidation (TBK-active products) remained elevated, the level of antioxidant protection catalase and superoxide dismutase enzymes increased somewhat, which ensured the balance of the antioxidant system and a significant decrease in the number of patients with a reduced state of AOS (42.6% and 24.2%, p <0.05). The dynamics of changes in biochemical parameters of the blood was characterized by a decrease in the number of patients with cholestasis syndrome: from 20% to 6.7% of cases by the level of total bilirubin and from 60% to 30% (p <0.05) of direct bilirubin; with hypercholesterolemia (60% and 30%, p <0,05) with a decrease in cholesterol (5,9 ± 0,4 and 5,2 ± 0,4) mmol / l and blood glucose (6,2 ± 0,4 and 5,6 ± 0,3) mmol / l, which indicates a certain positive dynamics in the treatment of hepatoprotectors and antioxidants non-alcoholic steatohepatitis associated with herpesvirus infection in the victims of the Chernobyl accident. As a result of the work, 5 scientific papers have been published, 1 report has been made at the conference. Product Description popup.authors Альохіна С.М. Гасанова О.В. Кадюк О.М. Плескач О.Я. Саркісова Е. О. popup.nrat_date 2020-04-02 Close