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Information × Registration Number 0218U001405, 0116U006301 , R & D reports Title To study the relationship between bronchopulmonary lesions and radiation-associated immunity changes in a remote post-accident period popup.stage_title Head Sushko V.A., Shvaiko L.I., Registration Date 08-02-2018 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Aim: to characterize the clinical and functional status of the bronchopulmonary system, immunological, molecular genetic indicesthe of the liquidators of the Chernobyl accident, depending on the dose and analyze their relationship. We examined 80 liquidators of the Chernobyl accident with chronic nonspecific lung diseases in the remote period after the disaster, and a 20 persons of comparison group, patients with chronic nonspecific bronchopulmonary disease without formed nosological form in bronchopulmonary disorders. The flow of COPD in the affected by the Chernobyl disaster group was accompanied by a significantly greater number of related diseases compared with nosology control. The results bodipletyzmografy in patients with COPD, the liquidators of the Chernobyl accident, there is a significant violation of the lung volumes ratio due to significant increase in residual volume and total lung capacity compared with the nosology control. Decreasing the number of CD3+ T cells, mainly by CD8+ subpopulation, while the number of CD4 + cells were significantly higher, compared with the control group, lower cytotoxic CD3+16+56+ T-lymphocytes, increase CD3-16+56+ increase CD 3-19+ B lymphocytes Is noted. Dose dependence of the number of TCR-variant lymphocytes of peripheral blood and relative length of telomeres (RTL) in patients with COPD and persons without formed in the nosological form of broncho-pulmonary system disorders at this stage of the research was not revealed. Product Description popup.authors Ільєнко Ірина Миколаївна Бєляєв О.А. Базика Костянтин Дмитрович Лясківська О.В. Ряжська Альна Сергіївна Стаднійчук Олена Миколаївна Харченко Татьяна Павлівна popup.nrat_date 2020-04-02 Close