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Information × Registration Number 0218U001406, 0116U003570 , R & D reports Title Identification of clinical and functional peculiarities of the non-cancerous endocrine disease course in persons exposed to ionizing radiation after the Choprnobyl accident and optimization of diagnostics and correction of the revealed disorders popup.stage_title Head Kaminsky Oleksij Valentinovich, Доктор медичних наук Registration Date 08-02-2018 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Object of the study: retrospective assessment of clinical data on the state of the central and peripheral parts of the endocrine system of the survived adults who were irradiated as a result of the Chernobyl accident at a young age and their descendants. The average external radiation dose was 0.187 Gy for adults; children irradiated at the age of 10-17 years have had received within 0.1-1.55 Gy radiation dose on thyroid. Verified clinical data were obtained during the examination of persons in outpatient or inpatient settings. Objective of the study: to determine the peculiarities of the course of non-malignant endocrine disease in remote term of the Chernobyl accident. Methods of research: generally accepted clinical, anthropometric (body weight, height, body mass index), instrumental (arterial pressure, ECG, ultrasound examination of the thyroid gland, pterygoid glands), laboratory (biochemical, hormonal), and statistical. The state of the endocrine system has been clarified during the implementation of the research project stage. The features of the non-malignant endocrine disease have been determined, the condition of parathyroid glands in the ChNPP accident survivors of adult and pediatric age has been investigated for the first time in the remote period of the accident. It has been established that frequent non-malignant endocrine disease, which is manifested in the the Chernobyl nuclear accident survivors irradiated at a young age, is the nodular goiter frequency of which is 3 times higher (26.7%) than in the control group (p <0, 05). In irradiated persons exposed to the unfavourable factors of the Chernobyl accident the thyroid disease is formed reliably earlier (5-10 years) than in uninvited individuals, which occurs in the face of body weight excess, hyperinsulinemia and insulin resistance, which deepen the progress of proliferative processes in thyroid . For the first time, an increase in the incidence of clinically significant parathyroid hyperplasia (more than 9 mm in adults and more than 5 mm in children) was observed in persons exposed to the Chornobyl accident (28.64%) and their descendants (23.8 - 70.6%), first of all in those who live in contaminated areas in adult age compared with the control group. Another group of risk was the persons evacuated from the 30-km exclusion zone - the category of people who were exposed to absorbed isotopes of iodine in the early days of the Chernobyl accident. The extent of implementation - 42 scientific papers, 1 monograph, 9 articles, 32 conference abstracts (of which 1 abroad) were published, 11 reports were presented at conferences (1 of which abroad). The field of use is radiation medicine, clinical endocrinology. Product Description popup.authors Афанасьєв Дмитро Євгенович Камінський Олексій Валентинович Копилова Ольга Василівна Муравйова Ірина Миколаїна Пронін Олексій Володимирович Чикалова Ірина Григорівна popup.nrat_date 2020-04-02 Close