Search academic texts

Information × Registration Number 0218U001407, 0116U003571 , R & D reports Title Study of structure and functional changes in thyroid gland in patients wiht benign and malignant tumors of the breast, which suffered from assident on CAES. popup.stage_title Head Lytvynenko Alexsandr Alexsandrovich, Registration Date 08-02-2018 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Object of research: structural and functional changes in thyroid gland in patients with malignant neoplasms in the mammary glands affected by the Chernobyl accident (35 people). The purpose of the work is to study the nature of changes in thyroid gland in patients with malignant neoplasms of the mammary glands affected by the Chernobyl accident. Methods of research: general-clinical, radiological, ultrasonographic, biochemical, morphological, immunohistochemical, statistical. Results and their novelty. Structural changes in thyroid gland in patients with breast cancer patients affected by the Chernobyl accident and living in contaminated areas are diagnosed at 82.86%. Changes in indicators of functional thyroid function at 28.51%. An elevated level of markers of the reproductive panel in patients with malignant neoplasms of the MR was found in 14.28% of patients. The elevated estradiol level at 2.85%, prolactin at 11.43%, and even 28.57% of the digital values of prolactin were at the upper limit of norm and progesterone at the lower limit of 25.7%. The estrogen receptors in the breast cancer tissue were detected in 73.53% of patients, progesterone in 58.82% of patients. The index of activity of cell proliferation - Ki - 67 was at the level of up to 20% - in 17, 65% of patients, in 11,76% of patients at the level of 20% and from 20% to 70% was 61,76% of patients. Structural changes in thyroid in patients with benign neoplasms of MH were diagnosed at 81.82%. Product Description popup.authors Антоненко Юрій Віталійович Бугайцов Сергій Георгійович Краснопольська Оксана Сергійовна Поліщук Валентин Віталійович popup.nrat_date 2020-04-02 Close