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Information × Registration Number 0218U001408, 0116U003572 , R & D reports Title Neyropsyсhobiological mechanisms of the mood and cognitive disorders in the exposed persons as a result of the Chernobyl disaster considering polymorphisms of genes. popup.stage_title Head Loganovsky Konstantin, Registration Date 08-02-2018 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Purpose: the definition of neuropsychiatric, psychophysiological, neuropsychological features of cognitive and affective disorders and gene polymorphisms in the survivors after the Chernobyl accident in the remote period of irradiation. The object of the research is the clean-up workers after the ChNPP accident, irradiated in utero as a result of the Chernobyl accident and unexposed control. In the clean-up workers after the ChNPP accident with depressive symptoms there is a greater level of somatic concern, anxiety, feelings of guilt, tension and excitement. They develop cognitive deficits, which leads to social dysfunction, detected dose-dependent deterioration of information processes and cognitive functions with predominant localization of pathological changes in the left frontal and temporal area of the brain and the Vernicke zone. In the prenatally exposed individuals, a specific neurocognitive and emotional and behavioral deficit is confirmed, which consists in preserving the intellectual development disharmony revealed at the expense of a relative decline in verbal intelligence; somatoform, anxiety and depressive disorders. The dose-dependent decrease in theta-band kEEG, indicating radiation damage of the hippocampus. Intercostal amplitude-time changes of auditorium cognitive potentials reflecting violations of neurodevelopment are revealed. The distribution of polymorphisms of the serotonin transporter gene SLC6A4 reflects the general population. In clean-up workers after the ChNPP accident with intermediate and low-function polymorphisms there is a tendency to increase mental and behavioral disorders, including depression, and among prenatally exposed individuals carriers of polymorphism S / S more persons who smoke, abuse alcohol and other psychoactive substances, and also feel social discomfort; In them the tendency to diffuse growth of beta-power kEEG is traced. Product Description popup.authors Абраменко Ірина Вікторівна Антипчук Катерина Юріївна Білоус Н.І. Бомко Марія Олександрівна Гресько Марина Володимирівна Крейніс Георгій Юрійович Куц Костянтин Володимирович Логановська Тетяна Костянтинівна Масюк С.В. Нечаєв С.Ю. Перчук Ірина Вадимівна popup.nrat_date 2020-04-02 Close