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Information × Registration Number 0218U001456, 0117U003912 , R & D reports Title Search of new effective antifungal agents - design, synthesis and testing popup.stage_title Head Palchykovska Larysa Gnativna, Registration Date 09-02-2018 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 The aim of the work was to create new compounds with a high antifungal effect - potential antifungal drugs against strains of fungi of the genera Fusarium sp. Aspergillus sp. and fungi of the genus Candida sp .. A virtual screening of a large number of structures in the model constructions of farnesyl and N-myristoyl transferases was carried out. Based on the results of computer prediction, 96 compounds were selected and synthesized, for which in vitro antifungal activity against 10 strains of the pathogens of the genera Fusarium sp., Aspergillus sp., And fungi of the genus Candida sp. 9 compounds demonstrated effective antifungal activity. The most sensitive were the fungi of the genus Fusarium sp .. The data obtained indicate that the activity of new test agents is the same, or exceeds the activity of the reference preparations of fluconazole and tebuconazole. Product Description popup.authors Коломієць І.М. Пальчиковська Л.Г. Платонов М.О. Сорокін О.С. Степанюгін А.В. Ширина Т.В. popup.nrat_date 2020-04-02 Close