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Information × Registration Number 0218U001547, 0116U002408 , R & D reports Title To develop the bioengineering technology of magnetic nanotheranostics of malignant tumors. popup.stage_title Head Orel Valery Emmanuilovich, Доктор біологічних наук Registration Date 22-02-2018 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 The object of study: phantom with metastases; Fe3O4 nanoparticles; digital images of phantom with metastases. Equipment: computer tomograph Toshiba Activion 16 TSX-031A/1C; magnetic resonance tomographs Signa Ovation (General Electric) and Philips Intera; ultrasonic diagnostic device Toshiba NemiоXG SSA-58A N E3E0862454; 300 mm measuring ruler. The purpose of work: to develop the bioengineering principles of the technology of magnetic nanotherapy of malignant neoplasms based on the combined use of magnetosensitive nanocomplex as therapeutic antitumor factor and contrast agent of radiation diagnostics. Research methods: physico-technical, physico-chemical, radiation diagnosis, laboratory and statistical. A phantom of liver metastases with nanoparticles was developed on the basis of original algorithm of bioengineering technology. It allows simulating small metastases in human liver. In order to increase the quality of artificial metastases visualization, iron oxide nanoparticles were used. The technology of phantom design allows changing the configuration of artificial metastases and their location in the physiological phantom, depending on the need. The studies on visualization of liver phantom with metastasis and nanoparticles have shown the following facts. Artificial metastases of ~ 5 mm in size without nanoparticles were almost not visualized by the methods of radiation diagnosis in contrast to metastases with nanoparticles, which were visualized well. The method of computed tomography had better efficiency for the integrated imaging of metastatic images with nanoparticles. The greatest contrast (Kp = 2.031) of liver phantom images for metastases with nanoparticles was obtained by ultrasound imaging. CT images had lesser contrast (Kp = 0.148). The maximum contrast Kp = 0.034 for the images of artificial metastases without nanoparticles obtained by MRI with magnetic induction B = 1.5 T was lesser in absolute value than the maximal contrast Kp = -0.733 of the image obtained by MRI with magnetic induction B = 0.35 T. Developed phantom with artificial metastases and nanoparticles and follow-up trials have shown that the developed technology of magnetic nanotherapy of malignant neoplasms based on a combination of the methods of radiation diagnostics and magnetic nanotherapy with the use of magnetic nanoparticles as active agents can in the future be used for further preclinical studies in vivo and subsequent implementation to clinical practice. Field: Oncology. Product Description popup.authors Орел Ірина Валеріївна Романов Андрій Вікторович popup.nrat_date 2020-04-02 Close