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Information × Registration Number 0218U001769, 0118U004713 , R & D reports Title Proton-sensitive ion channels as a pharmacological target in the treatment of epilepsy. popup.stage_title Head Maximyuk Oleksandr Petrovych, Registration Date 07-09-2018 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 Taking into account the data of the previous molecular modeling and biological research, directed synthesis of a series of new compounds of dichloric binary and fluorine-containing carboxydimines - inhibitors of proton-sensitive channels of ASICs has been carried out.Structural compounds have been confirmed by methods of nuclear magnetic resonance on protons, as well as chromatomass spectrometry.The activity of these compounds on the human ASIC1a channels in the cells of the HEK 293 line was investigated by the method of "patch-clamp".The property of these compounds was determined to inhibit the activity of hASIC1a in a concentration-dependent manner. Further biological research is planned. Product Description popup.authors Єгорова Олена Володимирівна Кришталь Олег Олександрович Максимюк Олександр Петрович popup.nrat_date 2020-04-02 Close