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Information × Registration Number 0218U001892, 0118U005109 , R & D reports Title Creating sulfur-containing derivatives of carbocyclic and heterocyclic systems - potential antithrombotic agents popup.stage_title Head Novikov Volodymyr, Registration Date 18-12-2018 Organization Lviv Polytechnic National University popup.description2 Structural design and synthesis of new sulfur-containing derivatives of carbocyclic and heterocyclic systems - analogues of active compounds-hits have been researched. A base of new carbocyclic and heterocyclic analogues of compound-hits was created. Experimental investigations of in vitro synthesized new sulfurous derivatives of carbocyclic and heterocyclic systems, starting products for their production and Bioparticles have been carried out, the influence of surface-active substances of microbial origin on antithrombotic activity in a mixture with synthesized sulfur compounds has been investigated.The inhibitory effect of 9,10-anthracen dithiocarbamates in vivo under different concentrations on ADP-dependent platelet aggregation and platelet aggregation induced by arachidonic acid has been shown to have a dose-dependent effect and has allowed to identify effective compounds of dithiocarbamate nature with antithrombotic action on PZT in the blood. In a study on the assessment of acute oral toxicity in vivo in white mice, it was found that the compounds studied were moderately toxic Product Description popup.authors Болібрух Л.Д. Зварич В.І. Лубенеь В.І. Монька Н.Я. Наконенчна А.В. Стасевич М.В. popup.nrat_date 2020-04-02 Close