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Information × Registration Number 0218U002030, 0115U000312 , R & D reports Title Determination of clinical and hematological, immunological and cytogenetic predictors of prognosis of myelodysplastic syndrome popup.stage_title Head Tretyak N.M., Доктор медичних наук Registration Date 02-01-2018 Organization Kiev Research Institute of Haematolojy and Blood Transfusion popup.description2 Object of study: patients with myelodysplastic syndrome (MDS), bone marrow, peripheral blood, blood serum of patients with MDS. The aim of the work: to evaluate the effectiveness of treatment with immunomodulatory drugs for patients with MDS in different periods of the disease compared with the use of cytostatic agents on the basis of clinical study - hematological, immunological changes and to determine the criteria for the transformation forecast of the MDS RAEB I and RAEB II and AML. Methods of research: general-clinical, cytological, immunological, cytogenetic, statistical. The analysis of clinical-laboratory, immunological data of 113 patients with MDS in the initial period and after therapy. The marker of cell proliferation Ki-67: its levels of expression in patients with MDS RAEB I and RAEB II, the interconnection with the course of the disease, without progressive and cumulative survival was studied. The study of the contribution of KI-67 to the formation of the response to cytotoxic and immunomodulatory therapy in patients with MDS has been conducted. It has been shown that the factors that can potentially be used to evaluate the response to treatment, the duration of the progressive MDS course, and the prognosis of resistance to therapy are expressions of the expression cluster of differentiation (CD) on the cells of myeloid origin. It was established that determination of the immunophenotype of bone marrow cells by flow cytometry at MDS, the intensity of CD 33, CD 34, CD 117, as well as the level of expression of Ki-67 cells of myeloid sprout has a high diagnostic and predictive value. Our studies show that expression levels of CD 33, CD 34, CD 117 and the nuclear factor of proliferation of Ki-67 are promising potential predictors of MDS progression, its transformation into AML. Product Description popup.authors Андреєва Світлана Василівна Басова Ольга Василівна Гордієнко Алла Іванівна Кубарова Валентина Олександрівна Перехрестенко Тетяна Петрівна Стародуб Галина Сергіївна popup.nrat_date 2020-04-02 Close