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Information × Registration Number 0218U002070, 0116U000185 , R & D reports Title To develop short-schemes for treatment of drug-resistant tuberculosis popup.stage_title Head Lytvynenko Nataliia Anatoliyvna, Registration Date 12-01-2018 Organization Institute of tuberculosis and pulmonology named by F. G. Yanovsky popup.description2 Object: 1279 patients with MDR TB. Aim: to determine the optimal chemotherapy regimens for patients with mono- and poly-resistence, RifTB, MDR and XDR TB depending on the number, amount of anti-TB drugs at the treatment regimen, the length of intensive and continuation phases of chemotherapy, which will increase the treatment efficasy and save public funds. Methods: clinical, radiological, laboratory, microbiological. A technology for the use of a 12-month abbreviation for antimycobacterial therapy in patients with multidrug-resistant TB has been developed, which allows, compared to the 20-month standard course, to improve the efficacy of treatment in patients with new cases of multi-resistant tuberculosis without resistance to aminoglycosides / polypeptides at the end of the main course of treatment with 69.8 % to 95.4% against the background of equally satisfactory tolerability of treatment, which reduces the total cost of treatment by 1.5 times among patients without resistance at fluoroquinolone or aminoglycoside / polypeptide and 2.4 times among patients with this resistance. The use of the 12-month reduced chemotherapy regimen compared to the standard 20-month course can increase the rate of "effective treatment" in patients with new cases of multi-resistant pulmonary tuberculosis with resistance to fluoroquinolones or aminoglycosides / polypeptides at the end of the course almost 2-fold ( from 46,9 % to 90,6 %). The effectiveness of the 12-month regimen at the end of the treatment compared to the end of the intensive phase was almost non-existent (90,6 % "effective treatment" and 96,9 % "bacterial withdrawal"). Sphere of application - phthisiology Product Description popup.authors Аврамчук Оксана Володимирівна Варицька Ганна Олександрівна Веселовський Леонід Вікторович Гранкіна Наталія Вячеславівна Грицова Наталія Анатоліївна Гульчук Наталія Михайлівна Давиденко Валентина Василівна Зайков Сергій Вікторович Кужко Михайло Михайлович Литвиненко Наталія Анатоліївна Пісковець Лариса Іванівна Погребна Марина Віталіївна Процик Любомир Миронович Рамзан Ніна Ігорівна Сенько Юлія Олександрівна Чоботар Оксана Петрівна Щербакова Леся Вікторівна popup.nrat_date 2020-04-02 Close