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Information × Registration Number 0218U002250, 0114U004392 , R & D reports Title Evaluation of the role of tumor-associated adipocytes in the impact of metabolic and stromal tumor microenvironment factors on the clinical course of tumor patients of different ages popup.stage_title Head Osynsky Sergy Petrovych, Registration Date 06-02-2018 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 For the first time using a large clinical material it was shown that cancer-associated adipocytes (CAAs) in tumor tissue and bone marrow of patients with gastric cancer (GC) are the hypoxia-dependent factor associated with tumor growth, with regional as well distant metastasis. The quantity CAAs and adiponectin positive cells in tumor are associated with appearance of tumor cells in places of distant metastasis and can be used in the control of disease outcome in particular of minimal residual disease. It was shown also that the number of factors of tumor microenvironment (microvessels density, tumor-associated macrophages, CD8+ and CD45RO+ cells, expression of homing-protein CXCR4 in tumor, activity of MMP-2) may be recommended to evaluate the disease outcome of certain categories patients with GC in dependent of age as well index of body mass. For the first time it was shown that dysfunction of adipose tissue is the modifier of tumor microenvironment and as a factor of aggressive phenotype formation. Defects in oxidative phosphorylation mechanism, increasing of the generation of superoxidic radicals (SR) and guanine oxidation in DNA, activities of MMP-2 and MMP-9 in adjoin fatty tissue (TAFT) activate the number of redoks-dependent factors in tumor that are the important ;indices of tumor progressing as GC as well rectum cancer (RC). High levels of generation SP and activities of gelatinases in TAFT are associated with distant metastasis and may have the prognostic value in the treatment of GC and RC. Product Description popup.authors Бубновська Л.М. Бурлака А П Вірко С.В. Вовк А.В. Галєєва А.М. Ганусевич І.І. Гуменюк Л.Д. Лукін С.М. Скороход А.Р. popup.nrat_date 2020-04-02 Close