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Information × Registration Number 0218U002322, 0115U003258 , R & D reports Title Molecular design of new heterocycles with pharmacophores based on multi-component and domino reactions with utilizing of diazonium salts popup.stage_title Head Mykola Dmytrovych Obushak, Registration Date 14-02-2018 Organization Ivan Franko National University of Lviv popup.description2 New synthetic approaches to the construction of the heterocycles of different classes based on multicomponent, tandem and domino reactions, were used from the available diazonium salts as a starting reagents. It was first successfully used in multicomponent reactions of the 5-arylfuran-2-carbaldehydes and 3-(5-arylfuran-2-yl)acroleine and expanded the boundaries of the using in the Gantsch, Biginelli, Radziszewski, and Ugi reactions. A novel multicomponent Ugi-Diels-Alder tandem reaction for the synthesis of isoindoles and furo[2,3-f]isoindoles were developed. An approach has been developed for the construction to compounds with the furan ring annulated with isoindoles ring, based on furfural and furylacrolein. A simple diastereoselective domino-reaction for the synthesis of hydrogenated thieno[2,3-f]isoindoles was proposed. A new three- and four-steps domino Knevenagel-hetero-Diels-Alder reactions were developed. Based on Gewald's aminothiophenes and functionalized 3-aminothiophenes and using the strategies of one-pot reactions, tandem and domino reactions, the methods for the synthesis of nitrogen-containing heterocycles, annulated with thiophene ring, have been developed. The general characteristics of the reactions of the methylene compounds with 1-nitroethenes and 2-nitrothiophenes, in which the attack of CH-acid occurs in the b-position to the nitro group, which in the next stage is intramolecularly recovered to the oxime group is revealed. The six- and five-membered heterocyclic compounds (pyridones, quinolones, 3-hydroxycumarines, substituted sidnons) have been investigated in the reactions with arenediazonium salts and the conditions of the reactions were founded. Among the synthesized compounds, were founded anti-tumor and antimicrobial active compounds, and there can be used in organic electronics, such as dyes and complexing agents for the determination of metal ions. Product Description popup.authors Горак Юрій Ігорович Литвин Роман Зіновійови Походило Назарій Тарасович Туриця Віктор Володимиович Шийка Ольга Ярославівна popup.nrat_date 2020-04-02 Close