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Information × Registration Number 0218U002432, 0115U002157 , R & D reports Title Development of optimal schedules of vaccination against bacterial infection in HIV-positive children receiving antiretroviral therapy popup.stage_title Head Chernyshova L. I., Registration Date 06-03-2018 Organization National Medical Academy of Post-Graduate Education named after P.L.Shupyk popup.description2 For the first time in Ukraine, there has been studied post-vaccination immunity to vaccine preventable bacterial (diphtheria, tetanus, H. influenzae type b) infections in HIV-infected children. For the first time, there has been studied immunological memory (B-lymphocytes CD27 +) in HIV-infected children with no immunity to diphtheria, tetanus, cortex who underwent antiretroviral therapy. For the first time in Ukraine, the duration and effectiveness of different antiretroviral therapy regimens in HIV-infected children has been compared. Of the 58 HIV infected children vaccinated against diphtheria and tetanus, the protective level of tetanus antibodies was determined in 72.4% (42/58) of children, diphtheria antibodies in 20.6% (12/58) of children. Of the 17 control children, tetanus antibodies were determined in 100% of children, diphtheria antibodies in 41.7% (7/17) of children.The main predictors of immune protection against diphtheria and tetanus were the early initiation of antiretroviral therapy (ART), vaccination after the ART initiation and a higher level of CD4 + T-lymphocytes at the time of the survey. Regarding the protective immunity level against tetanus, memory B-lymphocytes in HIV-infected children have been studied. There has been detected a decreased number of CD27 + IgD + memory B-lymphocytes of the splenic marginal zone and CD27 + IgD- memory B lymphocytes with immunoglobulin class switching synthesis in HIV-infected children who did not have the protective level of tetanus antibodies. Most (85%) of HIV-infected children have a virological efficacy of first -line ART with an average duration of 4.5 years. Based on the obtained results, there have been suggested changes on the vaccination of HIV-infected children who receive antiretroviral therapy to be included in the National Calendar of Prophylactic Vaccinations. Introducing the study results into practice will make it possible to increase the effectiveness of HIV-infected children immunization, to reduce the risk of infections, to reduce the mortality rate of HIV-infected children, to improve the patients' quality of life. Product Description popup.authors Бондаренко А. В. Волоха А. П. Гільфанова А. М. Лісовська Г. М. Лапій Ф. І. Раус І. В. Степановський Ю. С. popup.nrat_date 2020-04-02 Close