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Information × Registration Number 0218U003036, 0117U003259 , R & D reports Title Human pathology, from the molecular to the cellular level popup.stage_title Head Ryndych Alla Volodymyrivna, Доктор біологічних наук Registration Date 12-01-2018 Organization Institute of Molecular Biology and Genetics NASU popup.description2 The purpose of the work is to identify the mechanisms that can inhibit and support the metastatic potential of cancer cells. As a result of this step, it was shown that the scaffold proteins ITSN1 and ITSN2 in HEK293 cells form protein complexes with the RNA binding proteins Sam68, LARP6 and hnRNPK that are involved in mRNA processing and may participate in the reorganization of the actin cytoskeleton and the signaling cascades of the cell . Such interaction between the partner proteins is mediated by the SH3-domain of the proteins ITSN1 and ITSN2.5481 Product Description popup.authors Арешков П.О. Бобик В.І. Губар О.С. Гудзера О.Й. Заєць В.М. Капустян Л.М. Коваленко О.П. Крикливий І.А. Кропивко С.В. Крупська І.В. Негруцький Б.С. Новосильна О.В. Порубльова Л.В. Раєвський О.В. Скрипкіна І.Я. Тукало М. А. Філоненко В.В. Шалак В.Ф. Яковенко Л.Ф. Яремчук Г.Д. popup.nrat_date 2020-04-02 Close