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Information × Registration Number 0218U003039, 0115U002944 , R & D reports Title Development of panel of pharmacogenetic markers for prognosis of the course and efficiency of treatment of social important human diseases at Ukrainian patients. popup.stage_title Head Livshits Ludmila Avramivna, Лівшиць Людмила Аврамівна, Registration Date 12-01-2018 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 Calculation of the odds ratio showed that the presence of the allele ss469415590 ?G of the IFNL4 gene in the genotype is associated with a threefold increase in the relative risk of a poor response to antiviral therapy with peg interferon (OR = 3.06; CI 95%: 1.61-5.82). Based on the analysis of polymorphic variant + 30920 C> T of the VDR gene, the frequency of allele C in the group of patients with significant liver damage (0.58) was higher than the frequency of the corresponding allele in the group of patients with insignificant liver damage (0.47). It is shown that patients with hepatitis C, carriers of allele variant +3725 G / C of TLR 4 gene, have a high risk of fibrotic changes of the liver (OR - 11.11; ID: 2.70-45.66). Product Description popup.authors Городна Олександра Володимирівна Гулковський Роман Владиславович Лівшиць Ганна Борисівна Маяковська Анастасія Володимирівна Пампуха Володимир Миколайович Чернушин Сергій Юрійович popup.nrat_date 2020-04-02 Close