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Information × Registration Number 0218U003267, 0115U002696 , R & D reports Title The investigation possibility of modification the radiation-induced mutagenesis in human peripheral blood lymphocytes in vitro using astaxanthin popup.stage_title Head Pilinskaya Maria Andriivna, Доктор медичних наук Registration Date 30-01-2018 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Object : peripheral blood lymphocytes.Aim: set the frequency of different types chromosoms aberrations in peripheral blood lymphocytes of healthy volunteers after exposed to irradiation in vitro in the G0 and the G2-phases of the mitotic cycle, and possible changes of parameters DNA methylation. Methods: Cytogenetic, molecular genetic. Results: In the case of a compatible action of in vitro gamma irradiation in a dose of 1.0 Gy and astaxanthin at a concentration of 20 mg / ml, a decrease in the frequency of radiogenic markers - dicentric and centric rings at the G0 stage was established; At the G2 stage of the cell cycle, astaxanthin did not exhibit modifying properties, a change in the frequency of indicators of damage to DNA in lymphocytes in the stages G0 and G2 of the mitotic cycle, a change in the level of global methylation of DNA was detected. Fields of use: radiation genetics. Product Description popup.authors Єрємеева Марія Миколаївна Дибська Олена Борисівна Курінний Денис Аркадійович. Пілінська Марія Андріївна popup.nrat_date 2020-04-02 Close