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Information × Registration Number 0218U003435, 0117U006347 , R & D reports Title Molecular mechanisms of inflammatory chronic pain. popup.stage_title Head Voitenko N Ivanov, Registration Date 13-02-2018 Organization Department for special training National academy of science of Ukraine at Kiev University popup.description2 The mean frequencies of spontaneous excitatory synaptic events in retrogradely identified spino-pontine neurons of lamina I in isolated preparations obtained from rats with peripheral inflammation were, as a rule, significantly higher than the respective frequencies in control units. The amplitudes of such events in the experimental group were also greater than those in the control group, but the difference was not so convincing. It is obvious that the background ("spontaneous") excitatory synaptic bombardment of lamina I neurons is noticeably modified in the presence of peripheral inflammation. This should, in turn, lead to substantial modification of general excitability of such units (its increase). A final effect of such shifts would be some facilitation of transmission of nociceptive information to the pontine and thalamic structures. Such increased excitability of neuronal networks in the dorsal horn in general and in projection neurons of lamina I in particular can provide a significant contribution to the development of hyperalgesia related to chronic inflammatory states and to facilitation of generation of pain-related emotions. It has been shown, using the comet assay, that nucleoids obtained from the neurons display the kinetics of DNA exit that is typical for cells with high transcriptional activity. Product Description popup.authors Афанасьєва К.С. Білан П.В. Войтенко Н.В Дужий Д. Є. Сиволоб А.В. popup.nrat_date 2020-04-02 Close