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Information × Registration Number 0218U003594, 0115U001972 , R & D reports Title The generation of novel bioactive osteoplastic materials containig bone morphogenetic proteins for osteogenesis induction. popup.stage_title Head Korchynskyi Olexandr, Registration Date 18-04-2018 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 During the third year of work on the project we have compared in vitro and performed optimization of conditions for incorporation of mesenchymal precursor stem cells into osteoinductive matrices. We have showed that biodegradable polyuretan osteoplastic materials generated as a cooperative effort with Gdansk Polytechnical Univarsity, Gdansk, Poland are non-toxic and do not inhibit early stages and stimulate late osteoblast differentiation of mesenchymal precursor cells. Our data will provide an opportunity to select of most effective variants of polyuretan-based biodegradable osteoplastic materials with incorporated recombinant BMP preparations, primarily BMP2/7 heretodimers, aiming to enhance their osteoinductive properties and to evaluate perpectives for their optimization with the use of antiinflammatory 4-tiazolidone derivatives. Such data will be an important contribution to both deeper understanding of basic molecular mechanisms in BMP signalling and practical use in translational biomedicine amd medical practice. Product Description popup.authors Луцик Максим Дмитрович Стойка Ростислав Степанович popup.nrat_date 2020-04-02 Close