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Information × Registration Number 0218U003604, 0113U001607 , R & D reports Title The features of immune and endocrine disorders in HIV-infected patients and their dynamics on highly active antiretroviral therapy popup.stage_title Head Zhyvytsia Dmytro Heorhiiovych, Registration Date 19-04-2018 Organization State Institute "Zaporizhzhia Medical Academy of Postgraduate Education of Ministry of Health of Ukraine" popup.description2 In HIV-infected patients ART, 24 weeks after the start of treatment, the absolute amount of CD4-lymphocytes (by 57%), the relative number of CD4-lymphocytes (by 50%) and the immunoregulatory index (2-fold) are statistically significantly increased. In patients with HIV infection, there is a decrease in serum levels of dehydroepiandosterone, triiodothyronine and a tendency to decrease thyroxine, with a preserved level of thyroid stimulating hormone. With severe immune deficiency (the number of CD4-lymphocytes is less than 100 ?l-1), there is a tendency to increase serum cortisol levels. In HIV-infected IDUs, substitution maintenance therapy significantly increases the immunological and virological efficacy of ART after 48 weeks of treatment. In HIV-infected IDUs who did not receive substitution maintenance therapy in the period from 24 to 48 weeks of treatment, there is an increase in the number of patients with virological failure. Product Description popup.authors Живиця Людмила Василівна Казека Віталій Григорович Лимар Сергій Костянтинович Пономаренко Галина Фролівна popup.nrat_date 2020-04-02 Close