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Information × Registration Number 0218U003774, 0115U002443 , R & D reports Title Experimental substantiation of liposomal forms of drugs application for hypovolemic shock and traumatic and burn eye lesions popup.stage_title Head Khromov Alexandr Stanislavovich, Registration Date 19-07-2018 Organization State Establishment "Institute of Pharmacology and Toxicology National Academy of Medical Science of Ukraine" popup.description2 Physico-chemical properties and stability of the liposomal form of cytochrome c (Lipochrome), comply the requirements of the pharmacopoeial article "Liposomal preparations", DFU II edition. A single intravenous Lipochrome administration in the maximum volume doesn't lead to the death of animals and doesn't cause toxic effects, this allows to classify Lipochrome as a relatively harmless drug. Repeated intravenous Lipochrome administration for 14 and 28 days in the therapeutic or fivefold therapeutic doses also doesn't cause neither death of animals, nor signs of toxicity. Studies have shown liposomal drugs (Lipochrome, Lipoflavon) using possibility for correction of circulatory disorders with hemorrhagic shock. It is advisable combined use of liposomal drugs with infusion drugs, which are derivatives of hydroxyethyl starch. The use of Lipochrome in the delayed period of time prevents the development of syndrome of disseminated blood coagulation . On the model of light cataract, it has been established that eye drops "Lipochrome C" lead to the normalization of enzymatic disorders in the anterior chamber and lens moisture, prevent further development of cloudiness of the lens. Instillation or subconjunctious introduction of lipoflavone with thermal burn of the cornea reveals a clear anti-inflammatory and anti-edema activity, stimulates regenerative processes. By reparative activity, subconjunctival injection exceeds instillation. The introduction of lipoflavone causes improvement in the dynamics and acceleration of resorption of corneal opacity after thermal burn. Product Description popup.authors Блажчук І.С. Бойцова Л.В. Бондаренко Л.Б. Вороніна А.К. Гула Н.В. Данова І.В. Добреля Н.В. Карацуба Т.А. Коваленко В.М. Конахович Н.Ф. Матвієнко А.В. Мончак І.Л. Тишкін С.М. Хромов О.С. Шаяхметова Г.М. popup.nrat_date 2020-04-02 Close