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Information × Registration Number 0218U005392, 0114U003922 , R & D reports Title Features of viral and bacterial infections course depend on the genetic, morphological and metabolic factors popup.stage_title Head Moroz Larysa Vasylivna, Registration Date 16-11-2018 Organization Department of pharmacology course of clinical pharmacology Vinnitsa National Pirogov Medical University popup.description2 In the thesis the definitions of predictive factors of efficacy of antiviral therapy in patients with CHC are given. They are based on the evaluation of clinical, biochemical, serological, molecular-biological, molecular-genetic (rs 12979860 gene polymorphism IL-28B and ss 469415590 polymorphism of IFNL4) indices and morphological changes in the liver. It has been established that the SVR was achieved more frequently in patients with CHC who were the carriers of the TT/TT genotype of the IFNL4 gene than in carriers of the ?G/?G genotype. The predictive probability of achieving SVR by patients with CHC with genetic and clinical determinants has been established based on the MCMC model. Found the prevalence of TLR4 gene Asp/Asp genotype in patients with gastrointestinal form of salmonellosis. Asp allele was the most common. Gly allele of the gene TLR4 carriers were more often found among patients with salmonellosis. Gly allele was more common among severe patients. Application procedures QLIM found that the incubation period and duration of disease determine the severity of salmonellosis. Product Description popup.authors Палій Дмитро Володимирович Романчук Катерина Юріївна popup.nrat_date 2020-04-02 Close