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Information × Registration Number 0218U005602, 0118U003474 , R & D reports Title Develop an algorithm of laboratory diagnosis of hypersensitivity to anti-TB drugs in patients with pulmonary tuberculosis popup.stage_title Head Rekalova Elena Myhaylovna, Registration Date 28-12-2018 Organization Institute of tuberculosis and pulmonology named by F. G. Yanovsky popup.description2 The object of study is the peripheral blood of 36 patients with pulmonary tuberculosis (TB), 30 healthy individuals. The aim - to increase the efficiency of diagnostics hypersensitivity to anti-tuberculosis drugs by studying the immunological features of their intolerance in patients with TB. Methods - clinical, immunological, statistical.It has been established that the frequency of cases of hypersensitivity to anti-TB drugs (PTP) is determined in vitro by various immunological methods in patients with TB with clinical manifestations of intolerance to drugs was: to rifampicin in 75.0% - 87.5% of patients, isoniazidum - in 87.5% - 100.0% of patients; ethambutol - in 62.5% - 87.5% of patients. The peculiarity of immune status in patients with TB with manifestations of hypersensitivity to PTP is a significant increase in the content of leukocytes by 33.8%; an increase in the levels of immunoglobulins of class E in 194.1% of blood serum of patients with allergic manifestations compared with those of patients without symptoms of allergy; circulating immune complexes of small size in blood serum by 34,6% and anti-TB antibodies more than 4 times, indicating a more pronounced tumor of humoral immunity in patients with TB with manifestations of hypersensitivity to anti-TB drugs. The technology of laboratory diagnostics of hypersensitivity reactions to drugs in patients with pulmonary tuberculosis, which was to determine the intolerance of anti-TB drugs with the help of a test of erythrocytes sedimentation with the definition of the reaction to in vitro drugs in patients with TB with the development of software to optimize work with the analysis of the results obtained during the diagnosis, which allowed to reduce the time for processing one result of the analysis for the patient from 15-20 minutes to 2-3 seconds.Sphere of application - phthisiology, pulmonology, immunology. Product Description popup.authors Грабченко Наталія Іванівна Матвієнко Юлія Олеквандрівна Панасюкова Оксана Романівна Рекалова Олена Михайлівна Сінгаєвський Мирослав Богданович Ясирь Світлана Григорівна popup.nrat_date 2020-04-02 Close