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Information × Registration Number 0218U005603, 0118U003475 , R & D reports Title To study the role of immunological mechanisms of disadaptation in reducing the control of bronchial asthma popup.stage_title Head Feshchenko Yuriy Ivanovich, Registration Date 28-12-2018 Organization Institute of tuberculosis and pulmonology named by F. G. Yanovsky popup.description2 The object - 133 patients with bronchial asthma. The aim - is to improve the forecasting and prevention of uncontrolled flow of bronchial asthma on the basis of the study of the role of immunological mechanisms of maladaptation in reducing the control of this disease. Methods of research: general-clinical, immunological, statistical. It has been determined that 44.4% of patients have a controlled eosinophilia in the controlled BA, 44.4% decrease in the content of pan-T cells, an increase in the content of B cells in 88.9%, IgE levels in 33.3%. Reducing the content of phagocytic granulocytes with an increase of 2.6 times the production of phagocytes by active forms of oxygen provides sufficient anti-infective protection. With partially controlled asthma, leukocytosis, lymphocytosis, neutrophilosis, more pronounced eosinophilia, increased T-helper cells and decreased cytotoxic T-cells, which are signs of maladaptation, are confirmed by an increase in Ig E levels by about 5.5 times. It has been determined that in the case of uncontrolled asthma, the frequency of neutrophilosis and eosinophilia increases, the content of cytotoxic T-lymphocytes decreases in 45.8% of patients and NK cells in 47.8%, which indicates a further maladaptation, which is confirmed by the highest IgE levels at 54, 4%. Reducing the activity of phagocytic cells in patients with partially controlled and uncontrolled asthma may reduce the anti-infective defense and increase the risk of exacerbation of the disease. The technology for predicting uncontrolled flow of bronchial asthma has been developed, which allowed to predict the uncontrolled flow of asthma in 25.0% of patients, including in one third of patients with a partly controlled and uncontrolled course of it, and every tenth patient with a controlled course of illness before they had clinical signs of steroid resistance. Sphere of application - рulmonology Product Description popup.authors Ільїнська Ірина Федорівна Канарський Олександр Анатолійович Копосова Ірина Вікторівна Курик Леся Михайлівна Матвієнко Юлія Володимирівна Пархоменко Наталія Володимирівна Примушко Наталія Андріівна Турчина Інна Петрівна Фірсова Алла Сергіївна Фещенко Юрій Іванович popup.nrat_date 2020-04-02 Close