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Information × Registration Number 0218U006048, 0116U003350 , R & D reports Title Morphofunctional state of spleen and factors of immune reactivity in experimental carcinogenesis popup.stage_title Head Lisnychuk Natalia Yevgenivna, Кандидат біологічних наук Registration Date 14-03-2018 Organization Horbachevsky Ternopil State Medical Academy popup.description2 Under conditions of induced carcinogenesis, we observed significant enhancement of expression of the Bcl-2 gene in the spleen tissue of the experimental animals.At 30 weeks of observation, the number of cells expressing the Bcl-2 gene had been significantly increasing.At the edge of the red pulp, periarterial lymphoid muff, marginal zone, the red pulp retains the intensity of the reaction (+++). The positive reaction (++ -) is moderately pronounced in single cells, scattered around the periphery of the entire germinal center of white pulp.Determination of Ig A, Ig M, Ig G, Ig E concentrations showed that in case of chronic dimethylhydrazine defeat, destabilization of their synthesis took place.There increase in the concentrations of all studied classes of immune proteins in the blood serum of experimental animals was observed.The performed complex functional-morphological study allowed to find out the features of the course of immunological processes in the body of experimental animals.Under the conditions of experimental carcinogenesis, the whole spectrum of structural disorders of the spleen of the experimental animals is observed. Product Description popup.authors Андрійчук Ірина Ярославівна Волков Костянтин Степанович Калінічук Любов Олександрівна Крамар Соломія Богданівна Небесна Зоя Михайлівна Олещук Олександра Михайлівна Стравська Марія Ярославівна popup.nrat_date 2020-04-02 Close