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Information × Registration Number 0218U006762, 0115U000990 , R & D reports Title To optimize the treatment of children with purulent-inflammatory diseases with the regard for biorhythmic properties of microorganisms and features of the immune response popup.stage_title Head Davidenko Vyacheslav B., Доктор медичних наук Registration Date 04-09-2018 Organization 3.Kharkov national medical university popup.description2 Determined daily dynamics of production of pathogenicity factors and clinical strains S.aureusyE.coli set high enzymatic activity and formation of dense biofilms from planktonic cells following production at 9.00, at 12.00, at 15.00 and at 21.00, indicating that the adaptive response. It is proved that these fluctuations are adaptive in nature and depend on the time of administration of antimicrobial drugs in the clinical setting. Reference strains of S. aureustaE.coline had podibnyhdobovyh fluctuations. Established that ultrasound inhibits enzyme activity aggression, ability to bioplivkoutvorennya products and planktonic cells E.colita clinical strains of S.aureus. Also, a combination of ultrasound and ozone process formuvannyaneytrofilnyh activate traps, increasing the number of cells inactivated planktonic bacteria. Grounded new strategy to combat resistance patohennoyimikroflory using flexible regime protymikrobnoyiterapiyi days of the agreed time of maximum concentration of drug in the blood and minimum production factors and pathogenicity of maximum sensitivity of microorganisms to antibiotics Product Description popup.authors М'ясоєдов В.В. Мішина М.М. Пащенко В.Б. Штикер С.Ю. popup.nrat_date 2020-04-02 Close