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Information × Registration Number 0218U006801, 0115U000546 , R & D reports Title Influence of influenza vaccination on the course of comorbid conditions in patients with metabolic syndrome popup.stage_title Head Grishyna Olena Igorivna, Registration Date 12-09-2018 Organization The Mechnikov Research Institute of microbiology and immunology at Kharciv popup.description2 The object of the study was patients with metabolic syndrome (MS) and comorbid conditions. Objective: To study the patterns of immune response for seasonal influenza vaccination in patients with MS and associated comorbid conditions and to investigate the relationship between vaccination and the subsequent course of these diseases and, on this basis, to identify risk groups. Methods of research - epidemiological, clinical, instrumental, biochemical, immunological. Results and their novelty - Over the two epidemic seasons, the clinical effectiveness of vaccination has been evaluated. It was shown that it did not affect clinical and biochemical laboratory indicators, including carbohydrate metabolism. It was established that after the vaccination the content of lymphocytes CD2CD3, CD4, CD8, CD19CD22 increased; the Ig level of class M decreased; the levels of cytokines (interleukin (IL) 4, interferon gamma, tumor necrosis factor alpha, IL-6) increased. Characterized nonspecific immune response to vaccination in specific nosological forms. For the first time, the variant of the immune response that is characteristic for ineffective vaccination was singled out: initial low lymphocyte count, CD2 / CD3 and immunoregulatory index, and no increase in IL-4 level more than 2-fold after vaccination. Product Description popup.authors Бабінець Ольга Михайлівна Волянський Андрій Юрійович Грішина Олена Ігорівна Менкус Олена Валеріївна popup.nrat_date 2020-04-02 Close