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Information × Registration Number 0218U006943, 0117U002579 , R & D reports Title The role of peptidergic structures of hypothalamus and brain stem in the pathogenesis of arterial hypertension. popup.stage_title Head Kolesnуk Yuriі Mikhailovуch, Registration Date 23-10-2018 Organization Zaporozhye State Medical University popup.description2 On the basis of the experimental study, it was proved that arterial hypertension, which develops as a result of endocrine pathology and violation of the water-salt metabolism in rats is accompanied by significant changes in the morpho-densitometric indices of the studied neurons of the hypothalamus and the brain. At the same time an imbalance in the ratio and content of NOS isoforms is observed in the studied brain structures. Nitrites and nitrotyrosine content in the blood plasma of rats with simulated endocrine-salt hypertension increases by 18% and 19.5%, respectively in comparison with control group. The content of nitrites in the brain and hypothalamus homogenates is also higher than in the control group by 17% and 15.6%, respectively. Product Description popup.authors Іваненко Т.В. Абрамов А.В. Ганчева О.В. Данукало М.В. Ковальов М.М. Мельникова О.В. Тіщенко С.В. Федотова М.І. popup.nrat_date 2020-04-02 Close