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Information × Registration Number 0218U006946, 0115U003471 , R & D reports Title Development of technology for the creation of innovative new medicines based on antihypertensive and anti-ischemic biological active substances popup.stage_title Head Hladyshev Vitalii Valentynovych, Доктор фармацевтичних наук Registration Date 24-10-2018 Organization Zaporozhye State Medical University popup.description2 On the basis of complex technological, physico-chemical, biopharmaceutical, rheological, microbiological and pharmacological researches for the first time a composition and technology of the highly effective and stable diltiazem application semisolid dosage forms (rectal suppository and nasal gel) for cardiologic practice were proved scientifically and verified experimentally. Physico-chemical, technological, microbiological and biopharmaceutical properties of diltiazem application semisolid dosage forms (rectal suppository and nasal gel) were thoroughly investigated and methods of standartization were proposed. Specific activity was determined experimentally and biological safety of developed diltiazem application semisolid dosage forms for the rectal and nasal application was proved. Storage conditions, temperature regime, stability and shelf life of developed compositions were investigated. Product Description popup.authors Бурлака Б.С. Гладишева С.А. Количева Н.Л. Курінний А.В. Лисянська А.П. Фаді Ал Зедан popup.nrat_date 2020-04-02 Close