Search academic texts

Information × Registration Number 0218U007449, 0114U007007 , R & D reports Title Correction of endothelial dysfunction, oxide-reduction homeostasis and blood lipid spectrum in internal medicine practice. popup.stage_title Head Zolotariova Natalia Artemovna, Registration Date 18-12-2018 Organization Odesa National Medical University popup.description2 The paper presents the generalized results of the study of the features of endothelial dysfunction in patients with gout, arterial hypertension and their combination. It is established that such methods of detecting ED as FMD and determination of blood CE have approximately the same informative background in the absence of a statistical difference in their sensitivity (p = 0.71), therefore, in view of the greater labor intensity of the method of determination of blood CE, in clinical practice priority should be given It is precisely the definition of FMD. The most informative markers of ED in GA are elevation of levels of IL-1 and NO metabolites in the background of normal FMD, whereas in hypertension, elevated levels of ET-1 in the background of reduced FMD. With comorbid pathology, the most specific is the increase in levels of vWF, IL-1, ET-1 and decrease in FMD. Taking into account the low specificity and high variability of NO metabolites and NMD, their determination for diagnosis of ED is not feasible. Product Description popup.authors Золотарьова Ксенія Олегівна Золотарьова Наталія Артемівна Ковалевська Людмила Андріївна Медянка Юрій Степанович Писковацький Павло Михайлович Романченко Максим Ігорович Селіванов Віктор Володимирович Соломко Олена Володимирівна popup.nrat_date 2020-04-02 Close