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Information × Registration Number 0218U007465, 0116U008933 , R & D reports Title The pathophysiological mechanisms of the endothelial dysfunctions and hemostasis disorders at various pathophysiological conditions and also the pathogenetic substantiation of their correction. popup.stage_title Head Vastynov Ruslan, Registration Date 18-12-2018 Organization Odesa National Medical University popup.description2 Object of this research is adults (age - 2 months) white rats of the Wistar line weighing from 140 to 180 g. The research aims to determine the pathophysiological mechanisms of development of endothelial dysfunctions and disorders in various parts of the system of hemocoagulation during a metabolic syndrome in order to develop pathogenetically valid methods for their correction. Methods of research: pathophysiological, biochemical, clinical, laboratory, statistical. On the basis of biochemical study of the Willebrand factor, asymmetric dimethylarginine (ADMA), the amount of endogenous nitrates and nitrites, L-arginine and NO-synthase, 2,3-diphosphoglycerate (2,3-DPG) of erythrocytes was established the development of endothelial dysfunction and hypoxia on the background of chronic nitrate load., that deepen understanding of the pathogenesis of vascular lesions. Analysis also revealed the development of oxidative stress, as evidenced by changes in the indicators of the antioxidant system. Histologically confirmed endothelial dysfunction in the experimental conditions. Product Description popup.authors Вастьянов Руслан Сергійович Кірчев Владислав Віталійович М'ястківська Іванна Вікторівна Остапенко Ігор Олегович Савицький Іван Володимирович Садовий Олександр Сергійович Сарахан Василь Миколайович Стоянов Олександр Миколайович popup.nrat_date 2020-04-02 Close