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Information × Registration Number 0218U007466, 0116U008934 , R & D reports Title Development of new curative and preventive means and reasoning for their usage in combination treatment of oral lesions under exogenous and endogenous factors of risk. popup.stage_title Head Kravchenko Ludmila Sergeevna, Registration Date 18-12-2018 Organization Odesa National Medical University popup.description2 At experimental periodontitis against a background of hyperpeptic gastritis under conditions of smoking the considerable changes in periodontal tissues typical for the inflammatory process develop: lipid peroxidation activity rises and antioxidant system activity reduces, the markers of inflammation rise in case of reduction of nonspecific defence, the disbalance in the lipid peroxidation - antioxidant defence system and violation of the cytokine regulation develops in the blood serum. The local therapy of rats with the use of the new preparation "Apisan" resulted in correction of definite metabolic violation in the homogenates of gingiva and blood serum, accelerating removing harmful influence of damaging factors and restoring the state of periodontal tissue than using of comparison "Asepta" gel. The medical efficiency of the new gel "Apisan" consists in normalixing influence on processes of lipid peroxidation, inflammation and activation of the protective systems of oral cavity during periodontitis which arises up against a background of concomitant pathology of stomach - hyperpeptic gastritis. Product Description popup.authors Бас Олексій Андрійович Золотухіна Олена Леонідівна Кравченко Людмила Сергіївна Розовик Наталія Сергіївна Щербаков Сергій Васильович popup.nrat_date 2020-04-02 Close