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Information × Registration Number 0218U007821, 0118U004732 , R & D reports Title Design, synthesis and mechanism of action of new antiepileptic/neuroactive compounds for multidirectional regulation of GABA and glutamatergic neurotransmission for the treatment of epilepsy and other neuropathology. popup.stage_title Head Borisova Tatiana Alexandrovna, Registration Date 20-12-2018 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 Methods of obtaining and modifying of new antiepileptic/neuroactive compounds, thiopyrano [2,3-d]thiazoles and 3,5- and 2,5-disubstituted-4-thiazolidinones are optimized for multidirectional regulation of GABA and glutamatergic neurotransmission for the treatment of epilepsy and other neuropathology. Leading compounds were selected for further studies of neuromodulatory effects on the rat brain nerve terminals. The compounds that can cause depolarization of the plasma membrane of nerve terminals and reduce the acidification of synaptic vesicles, as well as those that can cause hyperpolarization of the plasma membrane and increase the acidification of synaptic vesicles, have been established. The compounds that can increase the extracellular level of neurotransmitters in the rat brain nerve terminals were found. Product Description popup.authors Борисов А.А. Дударенко М.В. Камінський Д.В. Крисанова Н.В. Крищишин А.П. Лесик Р.Б. Лозинський А.В. Пастухов А.О. Позднякова Н.Г. popup.nrat_date 2020-04-02 Close