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Information × Registration Number 0218U007830, 0116U004474 , R & D reports Title Mechanisms of development and compensation hypoxic and oxidative tissue damage in neurodegenerative and metabolic disorders popup.stage_title Head Mankivska Iryna M., Portnychenko Alla G., Mankovska Iryna М., Доктор медичних наук Registration Date 20-12-2018 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 Mechanisms of disturbances in oxygen supply of the brain and cytoprotection under neurodegenerative diseases (Parkinson's disease), as well as in arterial hypertension, associated with mitochondrial dysfunction, violation of respiratory regulation, inhibition of IGF-1 / IGF-1R / PI3K signaling pathways have been established in experimental and clinical studies. A mode of hypoxic therapy of patients with prediabetes, which increases the expression of insulin receptors and promotes recovery of the carbohydrate metabolism, was developed. The results are novel, fundamental and applied to the improved diagnostics and further development of non-drug treatments for neurodegenerative diseases. Product Description popup.authors І.В.Пономарьова І.М.Маньковська І.О.Барановська А.Г.Портниченко А.М.Сидоренко Бакуновський О.М. Братусь Л.В. В.І.Портніченко В.В.Бабічева Гавенаускас Б.Л. Гончар Є.В. Дубова М.Г. К.Р.Тимошенко Лінник О.О. М.І.Василенко Моісеєнко Є.В. О.Ю.Гарматіна Розова К.В. Серебровська Т.В. Ю.В.Путій popup.nrat_date 2020-04-02 Close