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Information × Registration Number 0218U007831, 0114U007233 , R & D reports Title Investigation of mechanisms of myocardial remodeling in the pathogenesis of heart failure and its correction popup.stage_title Head Dosenko Viktor Yevgeniyovych, Registration Date 20-12-2018 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 As a result of studies it was shown that the expression of gene NPPB encoding the components of sodium uretic system is significantly decreased during ageing and under hypertensive conditions. The expression of natriuretic peptide clearance receptor in heart tissue of old hypertensive rats was shown to be increased. It is also established that old hypertensive rats have decreased level of microRNA-1 and increased level of IGF-1 mRNA that may contribute to remod3eling of hert ventricles. Product Description popup.authors Є.В. Гончар А.М.Шиш А.С. Жуковська В.Є.Досенко В.Л. Гур'янова В.С.Нагібін Г.В. Портніченко Д.О. Строй Д.О.Пашевін З.О. Серебровська Л.В.Тумановська О.С. Панасюк Р.А. Ровенець Р.Б.Струтинський Р.О. Моргачов С.В. Гончаров Т.І. Древицька Т.О. Козак Т.Ю. Лапикова-Бригінська popup.nrat_date 2020-04-02 Close