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Information × Registration Number 0218U007841, 0118U006173 , R & D reports Title Thiamine derivatives and its structural analogs as inhibitors of cholinesterases. popup.stage_title Head Kobzar Oleksandr Leonidovych, к.х.н. Registration Date 21-12-2018 Organization V.P. Kukhar Institute of bioorganic chemistry and petrochemistry popup.description2 Thiamine derivatives and its structural analogues had been tested in vitro as inhibitors of cholinesterases. Among the tested compounds, effective and selective inhibitors of acetylcholinesteraseandbutyrylcholinesterase, with IC50 values in themicromolar and nanomolar range,were found. The possibility of binding of the thiamine derivatives and its structural analogues with serum albumin, the main transport protein inblood plasma, was shown. Product Description popup.authors О.Л. Кобзар popup.nrat_date 2020-04-02 Close