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Information × Registration Number 0218U007879, 0118U004713 , R & D reports Title Proton-sensitive ion channels as a pharmacological target in the treatment of epilepsy. popup.stage_title Head Maximyuk Oleksandr Petrovych, Registration Date 22-12-2018 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 Taking into account the data of the previous molecular modeling and biological research developed advanced techniques for the synthesis of polyhalogen-containing carboxydimines and polyfluoro derivative heterocyclic carboxydimin. Synthesized compounds are characterized by chromatospasm spectrometry and NMR spectroscopy methods on H1 nuclei. All synthesized compounds did not exhibit cytotoxic effects at concentrations up to 100 мкM / l. The activity of these compounds on the human ASIC1a channels in the cells of the HEK 293 line has been investigated. The property of these compounds has been found to inhibit the activity of hASIC1a in a concentration-dependent manner. Investigations of the influence of the most active compounds on behavioral reactions and electrical activity of the hippocampus of experimental animals in vivo have been carried out. Product Description popup.authors Єгорова Олена Володимирівна Кришталь Олег Олександрович Максимюк Олександр Петрович popup.nrat_date 2020-04-02 Close