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Information × Registration Number 0218U100001, 0118U002089 , R & D reports Title Creation of supramolecular systems for dosed release of physiologically active compounds into biological fluids popup.stage_title Head Turov Volodymyr V., Доктор хімічних наук Registration Date 06-12-2018 Organization Chuiko Institute of Surface Chemistry of NAS of Ukraine popup.description2 Report on research work: 88 p., 34 Fig., 3 Tabl., 77 referens The objects of the study are hydrophilic silica A-300, methylcellulose, a dispersed mixture of medicinal plants, bioactive compounds of amber, amber acid, Amanita muscaria mushrooms and composite systems based on them, The purpose of the development was to develop methods for managing the adsorption properties of nano-silica minerals and to create on this basis a new generation of composite systems containing a mineral base and biologically active substances of natural origin in which the rate of release of the active component is regulated by the mechanochemical treatment and hydrophobic-hydrophilic properties of the mineral matrix. Research methods - low-temperature 1H NMR spectroscopy, IR spectroscopy, electronic and optical microscopy, thermal analysis, quantum-chemical modeling. The main idea of the project was to regulate the rate of release of active substances from composite systems by structural modification of hydrophilic nanocrystal and inclusion in the composition of solid and liquid hydrophobic applications. As a result of the work, a simple method of wetting hydrophobic powders with water based on their mechanochemical sealing in water composites, the amount of which can range from 0.8/1 to 2/1 in relation to the weight of the hydrophobic powder powder, has been developed. As an example, nanosilver A-300 shows that water structures in interparticle gaps are represented by clusters with a radius of 2 and 5 nm, as well as a wide range of water aggregates with R> 10 nm. In this case, the inclusion in the interparticle gaps of hydrophilic silica particles of methyl silicate causes a radical change in its ability to bind water. It was to be expected that hydrophobic particles, bind in the process of compositing, the van der Waals couplings with hydrophilic silica particles would reduce its ability to adsorb water. Product Description popup.authors popup.nrat_date 2020-04-02 Close