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Information × Registration Number 0219U000002, 0118U001910 , R & D reports Title Investigation of the effects of nanocomposite Feroplat on the structural and functional harametrs of breast cancer cells popup.stage_title Head Lukianova Nataliia Yuriivna, Registration Date 03-01-2019 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 It was established that the manifestation of the Feroplat cytotoxic action is a violation of the cytoarchitectonics of the cells of the hormone-negative breast cancer cell line, dystrophic changes in the form of organelles, cytoplasm, and nuclei vacuolatio, as well as damage to the DNA structure. It was determined that one of the mechanisms of Feroplat influence of is the change of epigenetic regulation of proteins, involved in apoptosis and intercellular adhesion regulation. Described violations led to blocking the cell cycle, apoptotic death of cells by the mitochondrial pathway, and reducing their invasive potential. The obtained data reveal the prospect of using Feroplat in the treatment regimens of triple- negative breast cancer. Product Description popup.authors Борікун Тетяна Вікторівна Горбик Дарья Миколаївна Лозовська Юлія Валеріївна Лук'янова Наталія Юріївна Налєскіна Леся Анатоліївна Тодор Ігор Миколайович Чехун Василь Федорович popup.nrat_date 2020-04-02 Close