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Information × Registration Number 0219U000006, 0118U005125 , R & D reports Title New multifunctional hybrid nanocomposites for photodynamic chemotherapy of malignant tumors popup.stage_title Head Chekhun Vasyl Fedorovych, Registration Date 03-01-2019 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 Multi-component nanosystems based on star-shaped copolymers Dextran-Polyacrylamide, Gold nanoparticles, photosensitizer (Chlorin e6) and doxorubicin have been synthesized and characterized. It is proved that all nanosystems synthesized in branched polymer matrices are time-stable (the size of gold nanoparticles is practically unchanged) and have a size suitable for use in experiments invitro. It has been established that in the presence of a photosensitizer or doxorubicin, an insignificant process of aggregation in the system occurs due to the change in the hydrophilic-hydrophobic balance of the polymer matrix. It is proved that the greatest cytotoxic effect of nanosystems Polymer / Nanoparticles of gold / Chlorin e6 / Doxorubicin in combination with PDT is performed on human breast cancer cells, especially those resistant to doxorubicin. Product Description popup.authors Борікун Тетяна Вікторівна Гарагуц Юлія Іванівна Горбик Дарья Миколаївна Задворний Тарас Володимирович Куцевол Наталія Володимирівна Лук'янова Наталія Юріївна Науменко Антоніна Прокопіївна Чехун Василь Федорович Чумаченко Василь Анатолійович Ящук Валерій Миколайович popup.nrat_date 2020-04-02 Close