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Information × Registration Number 0219U000052, 0114U003213 , R & D reports Title Studying of biochemical mechanisms of excitation-contraction coupling in smooth muscle cells. popup.stage_title Head Kosterin Sergiy Oleksiyovuch, Registration Date 10-01-2019 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 It has been proven crucial role of calix[4]aren C-90 sulfonylamidine groups in the inhibition of plasma membrane Са2+,Mg2+-ATPase activity. This compound acts as a complete noncompetitive inhibitor for the plasma membrane Ca2+,Mg2+-ATPase. Calix[4]aren C-97 and C-99 at a concentration of 100 nM inhibited Са2+ accumulation in isolated mitochondria of smooth muscle and reduced the concentration of this cation in the matrix. It was shown the ability of calix[4]aren C-99 to penetrate through the smooth muscle cell plasma membrane and its influence not only on the ATPase activity of myosin, but on the integrity of the aktomyosin complex. Nitric oxide or its derivatives moderately reduce the mitochondrial transmembran potential, which is confirmed by the flow cytometry data. It is proven that antagonists of calmodulin reduce the level of polarization of myometrial mitochondria membranes. Product Description popup.authors Бабіч Лідія Григорівна Бевза Олександр Васильович Векліч Тетяна Олександрівна Данилович Ганна Вікторівна Данилович Юрій Володимирович Карахім Сергій Олександрович Лабинцева Раіса Дмитрівна Чуніхін Олександр Юрійович Шкрабак Олександр Анатолійович Шликов Сергій Георгійович popup.nrat_date 2020-04-02 Close