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Information × Registration Number 0219U000060, 0118U006093 , R & D reports Title Development of new nanosize calixaren effectors of АТР-dependent enzymes and cation-transporting systems popup.stage_title Head Babich L.G., Registration Date 10-01-2019 Organization Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine popup.description2 It was shown that a short-term incubation (5-10 min) of mitochondria in the presence of calix[4]arene chalcone amides (10 µM), which contain from two to four chalcone amide groups, increased the level of mitochondria membranes polarization, ionized Ca concentration in the matrix and have different effects on the mitochondrial volume. It was proved that calix[4]arene chalcone amides (С-138, С-137, С-1023 та С-1011) inhibited with varying efficiency the oxidation of endogenous nucleotides in the electron transport chain. Enhance the generation of reactive oxygen species is observed at the presence of calix[4]arene chalcone amides C-1023 and C-1011, that can lead to oxidation stress and mitochondrial dysfunction. It is shown that all studied calix[4]arene chalcone amides C-138, C-136, C-137, C-1012, C-1021, C-1023, C-1024 and C-1011 slightly activate Са2+, Mg2+-ATPase and Na+, K+-ATPase of plasma membrane: 5-10% relative to control value. The activity of the Mg2+-ATPase was inhibited by these calix[4]arene chalcone amides. Product Description popup.authors Векліч Тетяна Олександрівна Данилович Ганна Вікторівна Данилович Юрій Володимирович Костерін Сергій Олексійович Шкрабак Олександр Анатолійович Шликов Сергій Георгійович popup.nrat_date 2020-04-02 Close