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Registration Number

0219U000505, 0116U003204 , R & D reports

Title

To develop methods of surgical treatment of aortic arch hypoplasia in congenital heart defects

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Head

Lasoryshynets Vasyl Vasylyovych,

Registration Date

01-02-2019

Organization

M.M.Amosov National Institute of Cardio-Vascular Surgery of the Academy of Medical Sciences of Ukraine

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SRW report: 122 pages, Fig. 22, tab. 21, 120 sources of literature The object of the study: is patients with congenital heart disease (CHD), which are accompanied by hypoplasia of the aortic arc, namely: isolated hypoplasia of all segments of the artery of the aorta, abnormalities of the aortic arch, hypoplasia of the left heart in conjunction with the hypoplasia of the aortic arch, hypoplasia of the aortic arch with ventricular septal defect (VSD), aortic-pulmonary window, and transposition of great vessels. The aim of the study: is to improve the results of surgical treatment and quality of life of patients with hypoplastic aortic arch through the improvement of diagnosis, treatment tactics and surgical techniques. Methods of research: general-clinical, physical, laboratory, instrumental (electrocardiography, x-ray of chest organs in direct projection, echocardiography, computed tomography, catheterization of the heart cavities and major vessels with angiocardiography), statistical. The theoretical value of the results obtained during the research work is to thoroughly study the nature of the natural course of patients with hypoplasia of the aortic arch under CHD in preoperative and intermediate stages of surgical treatment and in the remote period, and to develop the tactics of surgical treatment of patients with this pathology. The scientific novelty of the results obtained due to the study of this topic give the possibility for authors developed a protocol for operative treatment of the CHD, which are accompanied by hypoplasia of the aortic arch, and also introduced new methods for correcting aortic arch in newborns with the obligatory optimization of brain protection, using cerebral perfusion. The practical value of the results of the work carried out is that on the basis of the research the main anatomical and clinical features of the hypoplastic aortic arch as a separate cardiosurgical syndrome and optimal terms and criteria of prenatal diagnosis of the aortic arch hypoplasia have been determined, as well as the role of echocardiography, angiocardiography and computed tomography at defined criteria for diagnosis of hypoplasia of the aortic artery in the postnatal period. A comparative analysis of various methods of plastic arc aorta based on the study of direct and long-term results has been created and optimized for the protection of the brain during operations for the hypoplasia of the aortic arch, defined risk factors for complications and death after the correction and developed algorithm for diagnosis and tactics of surgical treatment of patients with hypoplastic aortic arch. Neurological complications associated with antegrade cerebral perfusion was not.

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Головенко Олександр Сергійович
Дітківський Ігор Олександрович
Дзахоєева Людмила Сергіївна
Лазоришинець Василь Васильович.
Прокопович Лілія Михайлівна
Руденко Майя Миколаївна
Труба Ярослав Петрович

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2020-04-02