Total number
Full text
Total number
Full text
Number of local repositories
Full text
0219U000825,
0116U002160
,
Characteristic oxyphilic cell’s changes in papillary thyroid carcinomas depending on the time elapsed after the Chernobyl accident and the results of follow-up of patients
Tronko Mykola Dmytrovych; Bogdanova Tetiana Ivanivna,
28-02-2019
State institution "V.P. Komisarenko Institute of Endocrynology and Metabolism of the National Academy of Medical Science of Ukraine"
Object: Indicators of the incidence of thyroid cancer, histopathological characteristics of papillary thyroid carcinoma (PTC), oxyphilic cell's changes (OxyCh) in PTC. Purpose: to continue the incidence' monitoring of thyroid cancer in children and adolescents affected by the Chornobyl accident, compare the frequency of OxyCh, the invasive properties and the postoperative follow-up in the patients of different age groups with PTC born before the Chornobyl accident ("radiogenic" PTC) and after the accident ("sporadic" PTC) with the presence and absence of OxyCh. Methods: morphological, statistical. Theoretical and practical results: The incidence of thyroid cancer per 100,000 of the population in high-risk groups (children and adolescents at the time of the Chornobyl accident) in Ukraine as a whole, and in the six most affected northern regions, was characterized by rising time-trends during the period from 1990 to 2017. The difference between the indicators in the least and most affected regions persisted until 2017, which may indicate an additional radiogenic component of the disease in the contaminated regions of Ukraine for more than 30 years. Implementation of intraoperative frozen section studies (FSS) to a lesser extent, but more effective, prevents unjustified costs for additional materials and reagents for pathological diagnostic. The use of new "uncertain" pathological diagnoses of thyroid tumors according to the data received may reduce the volume of surgical interventions and improve the patient's quality of life. OxyCh are more common in "sporadic" than "radiogenic" PTC. In patients of "radiogenic" series, the average 131-I thyroid dose was significantly lower, but nodal disease recurrences (including those not sensitive to radioiodine therapy), on the contrary, were more frequent in the PTC with the OxyCh presence than in patients with PTC without OxyCh. Probably the increasing age-related trend of OxyCh' frequency in PTC of patients from "radiogenic" series and, on contrary, significant linear decreasing of 131-I thyroid doses may be associated with a gradual increase in the frequency of "sporadic" cases (for which OxyCh are more common) among patients of "radiogenic " series. The obtained results indicate that OxyCh presence are an important prognostic factor for the postoperative course of the disease. Effectiveness of the implemented: the proposed standardized protocol for the performance of FFS improves their effectiveness and reduces the cost of pathological diagnostic of thyroid tumors. The application of the new WHO histology classification will prevent excessive radicalization of surgical intervention and improve the treatment of patients with thyroid tumors. Field of use: pathology, endocrine surgery, endocrinology, oncology.
Богданова Т.І.
Болгов М.Ю.
Бурко С.В.
Воскобойник Л.Г.
Гулєватий С.В.
Гулак Л.О.
Дегтярьова Т.Л.
Зурнаджи Л.Ю.
Мазурик Н.Я.
Плиска Н.П.
Терещенко В.П.
Тронько М.Д.
Шпак В.М.
2020-04-02
Updated: 2025-12-08
Saving a scientific data set occurs in two stages:
1.) Creating a data set
Enter the name of the set, a brief description of the set (annotation), and click the “Create set” button. After that, a draft data set will be automatically created, which you can save for further work with the set. The system will redirect you to the “Data set information” page.
2.) Filling in the data
On the “Data set information” page, you need to fill in all the fields related to the data set and upload the files.
Please note! Each file is uploaded separately. This is done to ensure the stable operation of the system.
Once you have filled in the information about the scientific data set and added the necessary files, you can save the draft or send the data to the system.
Please note! Once the data has been sent, you cannot change it.
Drafts are necessary for storing the data set and editing it before sending.
All accounts on the NRA website go through a standard registration procedure and are verified. However, in order to obtain additional features, such as publishing open reviews of academic texts, verification by affiliation is required.
To obtain the status “verified”, you must change your primary email address to a corporate one, which is tied to a scientific or educational institution.
For example: user@ukrintei.ua, user@nas.gov.ua
After confirming your corporate email address, your account will be automatically verified by affiliation.
If your email address is corporate, but your account does not have a verification mark, you need to write to us at the email address NRAT@ukrintei.ua. After verification, we will add your address to the database, and your account will be verified.
After completing the verification procedure for affiliation, you can change the primary email address to a convenient one for you, without losing your status during the current verification.
You only need to verify for affiliation once.
* We use corporate addresses from the Unified State Database on Education and the State Register of Scientific Institutions Supported by the State
To search for news published on the official website of NRАT in the “News” section, you need to enter one word, several words, or an exact phrase in the search field. Different terms are separated by spaces.
The search is performed everywhere – in the title and the news text.
For a more comprehensive result, it is recommended to use word stems (parts of words without endings).
When using multiple words for the search, they are combined using one of the logical methods described below.
By default, the logical connector “and” is used. In this case, search results will include all news releases that contain the specified words, even if they are located separately from each other and are in different parts of the text.
Example: Search phrase: OECD report. Search result: all news containing the words “report” and “OECD” in the text and in the title, both together and separately.
If a phrase or phrase is enclosed in quotation marks (“), the results will include all publications where this exact phrase or phrase is found.
Example: Search phrase: “OECD report.” Search result: all news containing the exact phrase “OECD report.”
If you know the publication date of the news or are interested in a specific time frame in which they were published on the website, you can select such a date or date range in the additional field that looks like a calendar. The date is entered in the format year-month-day and confirmed by clicking on the corresponding date in the calendar dropdown. You can enter a date or choose one by browsing through the calendar by months and years. By default, the interval starts from the oldest date (2018-01-23) and ends with the current date.
You can also use one or more hashtags, which are located under the search field on the right side of the “News” page.
Please note: The search for academic texts is carried out in a separate search window at the following link https://nrat.ukrintei.ua/searchdb.
