Search academic texts

Information × Registration Number 0219U000825, 0116U002160 , R & D reports Title Characteristic oxyphilic cell’s changes in papillary thyroid carcinomas depending on the time elapsed after the Chernobyl accident and the results of follow-up of patients popup.stage_title Head Tronko Mykola Dmytrovych; Bogdanova Tetiana Ivanivna, Registration Date 28-02-2019 Organization State institution "V.P. Komisarenko Institute of Endocrynology and Metabolism of the National Academy of Medical Science of Ukraine" popup.description2 Object: Indicators of the incidence of thyroid cancer, histopathological characteristics of papillary thyroid carcinoma (PTC), oxyphilic cell's changes (OxyCh) in PTC. Purpose: to continue the incidence' monitoring of thyroid cancer in children and adolescents affected by the Chornobyl accident, compare the frequency of OxyCh, the invasive properties and the postoperative follow-up in the patients of different age groups with PTC born before the Chornobyl accident ("radiogenic" PTC) and after the accident ("sporadic" PTC) with the presence and absence of OxyCh. Methods: morphological, statistical. Theoretical and practical results: The incidence of thyroid cancer per 100,000 of the population in high-risk groups (children and adolescents at the time of the Chornobyl accident) in Ukraine as a whole, and in the six most affected northern regions, was characterized by rising time-trends during the period from 1990 to 2017. The difference between the indicators in the least and most affected regions persisted until 2017, which may indicate an additional radiogenic component of the disease in the contaminated regions of Ukraine for more than 30 years. Implementation of intraoperative frozen section studies (FSS) to a lesser extent, but more effective, prevents unjustified costs for additional materials and reagents for pathological diagnostic. The use of new "uncertain" pathological diagnoses of thyroid tumors according to the data received may reduce the volume of surgical interventions and improve the patient's quality of life. OxyCh are more common in "sporadic" than "radiogenic" PTC. In patients of "radiogenic" series, the average 131-I thyroid dose was significantly lower, but nodal disease recurrences (including those not sensitive to radioiodine therapy), on the contrary, were more frequent in the PTC with the OxyCh presence than in patients with PTC without OxyCh. Probably the increasing age-related trend of OxyCh' frequency in PTC of patients from "radiogenic" series and, on contrary, significant linear decreasing of 131-I thyroid doses may be associated with a gradual increase in the frequency of "sporadic" cases (for which OxyCh are more common) among patients of "radiogenic " series. The obtained results indicate that OxyCh presence are an important prognostic factor for the postoperative course of the disease. Effectiveness of the implemented: the proposed standardized protocol for the performance of FFS improves their effectiveness and reduces the cost of pathological diagnostic of thyroid tumors. The application of the new WHO histology classification will prevent excessive radicalization of surgical intervention and improve the treatment of patients with thyroid tumors. Field of use: pathology, endocrine surgery, endocrinology, oncology. Product Description popup.authors Богданова Т.І. Болгов М.Ю. Бурко С.В. Воскобойник Л.Г. Гулєватий С.В. Гулак Л.О. Дегтярьова Т.Л. Зурнаджи Л.Ю. Мазурик Н.Я. Плиска Н.П. Терещенко В.П. Тронько М.Д. Шпак В.М. popup.nrat_date 2020-04-02 Close