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Information × Registration Number 0219U000923, 0118U001551 , R & D reports Title Synthesis and analysis of new structural analogues of arginine and canavanine as components of metabolic antitumor therapy popup.stage_title Head Stasyk Oleh Volodymyrovych, Кандидат біологічних наук Registration Date 15-03-2019 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 The purpose of the work is to analyze the cytotoxic effects of natural and synthetic analogues of arginine, in particular, indospicine and NP170, on the viability and proliferative activity of tumor cells under arginine deficiency, as well as the ability of malignant cells to restore cell growth after cumulative deficiency of arginine and arginine analogues. It has been established that indospicine in the extract of Indigofera spicata exhibits its cytostatic and cytotoxic effects in the culture medium deprived of the individual amino acid arginine, inhibiting the ability of tumor cells to restore proliferation after prolonged starvation for arginine. An increase in the concentration of the above-mentioned synthetic analogue of arginine to 0.4 mM, equivalent to the concentration of arginine in the medium, did not lead to an increase in the cytotoxicity of the drug. In addition, the combined effect of fasting for arginine and the used synthetic analogue of arginine did not have a noticeable effect on the resumption of tumor cells proliferation after arginine starvation. Experimental studies using the recombinant human arginase to produce arginine deficiency will be continued. Product Description popup.authors Бобак Я.П. Вовк О.І. Маєвська О.М. Чень О.І. Чернишук С.В. Шуваєва Г.Ю. popup.nrat_date 2020-04-02 Close