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Information × Registration Number 0219U000924, 0118U001551 , R & D reports Title Synthesis and analysis of new structural analogues of arginine and canavanine as components of metabolic antitumor therapy popup.stage_title Head Stasyk Oleh Volodymyrovych, Кандидат біологічних наук Registration Date 15-03-2019 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 The object of the study is testing on cellular models natural and synthetic arginine (Arg) analogues as components of metabolic antitumor arginine starvation-based enzyme therapy. The purpose of the work is to analyse the cumulative effects of Arg analogues and Arg deprivation on the functioning of key signaling pathways that regulate the growth, survival and viability of human tumor cells. It has been established that the combination of deprivation of Arg and its analogues canavanine, thioarginine and indospicine in non-toxic under normal condition concentrations causes a rapid loss of proliferative potential and death of HCT-116 human colon cancer cells and SKOV3 human ovarian carcinoma cells, mainly due to caspase-dependent apoptosis. It is shown that the effect of the combination of analogues of Arg on the background of Arg fasting is mediated by such key signaling mechanisms as PI3K-Akt-mTOR and MAPK-ERK. Product Description popup.authors Бобак Я.П. Вовк О.І. Маєвська О.М. Чень О.І. Чернишук С.В. Шуваєва Г.Ю. popup.nrat_date 2020-04-02 Close