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Information × Registration Number 0219U000974, 0118U003734 , R & D reports Title New methods of combined treatment patients with metastatic tumors of the abdominal cavity, retroperitoneum and small pelvis popup.stage_title Head Kolesnik Elena, Registration Date 21-03-2019 Organization Ukrainian Research Institute of Oncology and Radiology popup.description2 Object of research: 789 patients with malignant neoplasms. The patients performed radical surgical and combined treatment on the basis of the research division of the tumors of the abdominal cavity and retroperitoneal space of the National Cancer Institute. The aim of the research: to improve the immediate and long-term results of combined treatment of patients with metastatic liver damage with colorectal cancer and malignant neoplasms of other sites by studying the metabolic predictors of the disease, developing a methodology for controlling progression and improving the existing algorithms for surgical treatment. The goal of the 2018 stage: to improve the immediate and long-term results of combined treatment of patients with metastatic liver damage with colorectal cancer and malignant neoplasms, and by metastatic defeat of other sites by studying the metabolic predictors of the disease, developing a methodology for controlling progression and improving existing surgical treatment algorithms. Methods of research: clinical, laboratory, instrumental, statistical. On the basis of our research, we conducted an analysis of literary data and under clinical conditions performed a study of the effectiveness of liver resections with malignant neoplasms of the genito-urethral tract, breast cancer, stomach, sarcomas, and others. nosologies that have been operated on for metastatic liver damage (retrospectively). Also, the direct results of treatment of patients with peritoneal carcenomatosis were studied by performing cytoreductive interventions in combination with intraperitoneal hyperthermic chemotherapy. The functional state of hepatocytes in the adjacent and remote anatomical zones was assessed in relation to the stroma of the metastatic center of mRCP by using flow cytometry, EPR spectroscopy and zymography. However, among the operated patients, there is a risk of activating the growth of "hidden" micrometastases of colorectal cancer in the resected liver by studying the level of superoxide radicals and NO. in liver tissues and evaluate their effect on relapse and survival. Product Description popup.authors Бурлака Антон Анатолієвич Звірич Віталій Васильович Колеснік Олена Олександрівна Копчак Костянтин Володимирович Лісний Іван Іванович Махмудов Дмитро Ельдарович popup.nrat_date 2020-04-02 Close