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Information × Registration Number 0219U001045, 0118U003121 , R & D reports Title Development of methods for asymmetric synthesis of compounds with potential biological activity popup.stage_title Head Kolodyaznyi O.I., Доктор хімічних наук Registration Date 09-01-2019 Organization V.P. Kukhar Institute of bioorganic chemistry and petrochemistry popup.description2 The purpose of the project is the development of methods for the synthesis of chiral organophosphorus compounds with potential biological activity and the synthesis of biologically active analogues of natural compounds. The stratagy of the work is the investigation of the stereochemistry of electrophilic substitution reactions at phosphorus atom. Electrophilic substitution in chiral phosphorus compounds proceeds at the center of high electronic density from the front-side with the retention of absolute configuration. The stereochemistry of the reactions of Arbuzov, Michaelis-Becker, Staudinger, Michael, Mannich, Appel, Atterton-Todd, Cory-Fuchs, etc. was analyzed. The flash-vacuum thermolysis of trimethylsilyl tert-butyl halofenphosphonates was studied. Stereoselective methods for the synthesis of alpha and gamma derivatives of tetradecapentaenoic acid isolated from tropical plants of Zanthoxylum bungeanum (Rutaceae), which posses interesting pharmacological properties, were developed. The studies were carried out on the world level, published in international journals with high impact factor and , and are scientifically and practically important. Product Description popup.authors Є.В. Гришкун А.О. Гудима А.О. Колодяжна О.О. Колодяжна С.Ю. Шейко popup.nrat_date 2020-04-02 Close