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Information × Registration Number 0219U001088, 0115U003632 , R & D reports Title Development of new analgesics based inhibitors of calcium-permeable AMPA receptors popup.stage_title Head Voitenko Nana Volodymyrivna, Registration Date 10-01-2019 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 Here, we utilized pharmacological and genetic inhibition of spinal PKC? in various schemes of pain treatment in an animal model of long-lasting peripheral inflammation. Pharmacological inhibition (pre- or post-treatment) reduced the peripheral nociceptive hypersensitivity and accompanying locomotive deficit and anxiety in rats with induced inflammation. These effects were dose-dependent and observed for both pain development and maintenance. Gene-therapy (knockdown of PKC?) was also found to relieve inflammatory pain when applied as pre- or post-treatment. Moreover, the revealed therapeutic effects were accompanied with the declined upregulation of CP-AMPARs at the DH synapses between primary afferents and sensory interneurons. Our results provide a new focus on the mechanism-based pain treatment through interference with molecular mechanisms of AMPAR trafficking in central pain pathways. Product Description popup.authors Іванова С.Ю. Білан П. В. Багатська О.В. Войтенко Н. В. Дромарецький А.В. Дужий Д.Е. Забенько Є. Кротов В.В. Паливода Л.Г. Шеремет Е.Ю. Яценко В.П. popup.nrat_date 2020-04-02 Close