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Information × Registration Number 0219U001342, 0118U002295 , R & D reports Title Determining the interaction of pharmaceutical nanocarriers with model phospholipid membranes. popup.stage_title Head Lisetskiy Longin Mykolayovych, Registration Date 25-01-2019 Organization Scientific-research department of alkali halide crystals with experimental manufacture STC "Institute for single crystals" NAS of Ukraine popup.description2 Preparation procedures of were developed and characterization was carried out for multi-compound model phospholipid membranes which mimic the cell membranes of stomach, skin, bacteria, etc. Critical importance of lipid composition was shown for a number of drugs with various mechanisms of membrantoropic action. Membranotropic effects of different cerium compounds were established. Stabilized nanoparticles of cerium oxide (diameter 2 nm and 10 nm) were shown to be indifferent to the model lipid membrane. Meanwhile cerium in cationic form (Се3+) caused essential increase of lipid package in the membrane. In the presence of cerium nitrate and cerium ammonium nitrate, membrane disruption took place. Generally, it was established that membranotropic effect of cerium is strongly dependent on its ionic surrounding. Product Description popup.authors Ващенко О.В. Касян Н.О. popup.nrat_date 2020-04-02 Close